Rhea Amlodipine Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Amlodipine besilate

Indications/Uses

1st-line treatment of HTN as a monotherapy to control BP. Reduces the risk of fatal CHD, non-fatal MI, stroke, coronary revascularization & hospitalization due to angina in CAD patients. 1st-line treatment of myocardial ischemia due to stable angina &/or Prinzmetals's or variant angina of coronary vasculature. In combination or as monotherapy for angina ie, refractory to nitrates &/or β-blockers.

Click to view Rhea Amlodipine detailed prescribing information

Dosage/Direction for Use

HTN & angina Initially 5 mg once daily. Max: 10 mg. CAD 5-10 mg once daily. Childn 6-17 yr HTN 2.5-5 mg once daily.

Click to view Rhea Amlodipine detailed prescribing information

Overdosage

View Rhea Amlodipine overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food: Do not take w/ grapefruit or grapefruit juice.

Contraindications

Hypersensitivity to amlodipine & dihydropyridines.

Click to view Rhea Amlodipine detailed prescribing information

Special Precautions

Increased risk of pulmonary edema in patients w/ NYHA III & IV heart failure of non-ischemic etiology. Impaired hepatic function. Pregnancy & lactation.

Click to view Rhea Amlodipine detailed prescribing information

Use In Pregnancy & Lactation

Click to view Rhea Amlodipine detailed prescribing information

Adverse Reactions

Headache, dizziness, somnolence; palpitations; flushing; abdominal pain, nausea; edema, fatigue.

Click to view Rhea Amlodipine detailed prescribing information

Drug Interactions

Increased systemic exposure w/ simvastatin. Increased plasma conc w/ strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir). Increased BP-lowering effects w/ grapefruit juice. Increased risk of hypotension w/ clarithromycin. Decreased plasma conc w/ CYP3A4 inducers eg, rifampicin, Hypericum perforatum. Risk of increased blood levels of tacrolimus.

Click to view Rhea Amlodipine detailed prescribing information

Storage

View Rhea Amlodipine storage conditions for details to ensure optimal shelf-life.

Description

View Rhea Amlodipine description for details of the chemical structure and excipients (inactive components).

Action

View Rhea Amlodipine mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Calcium Antagonists / Anti-Anginal Drugs

ATC Classification

C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Regulatory Classification

Presentation/Packing

Form

Rhea Amlodipine tab 10 mg

Packing/Price

100's (P925/box)

Form

Rhea Amlodipine tab 5 mg

Packing/Price

100's (P650/box)

Rhea Amlodipine

amlodipine

Manufacturer:

Pfizer

Distributor:

Philusa